Greenville, FL → Key West, FL
424 mi · 8h 28m (driving)
Current Risk
Medium Risk
Rain expected
Greenville
62°
29.0°
81°
27.5°
78°
26.0°
78°
Key West
78°
Trip Briefing
4 segments · 424 mi · 8h 29m
Weather
⛅ Partly cloudy
81°F, wind 4 mph
Rest Stops
14
Truck svc, Restrooms
Clear driving conditions expected
Rest stops in this segment:
- ● Love's Travel Stop
- ● Madison County Rest Area Eastbound 🚻
- ● Busy Bee Truck Stop
Weather May Slow Traffic
Active weather advisory — expect slower travel
Traffic Cameras
See recent road conditions along your route
Images are snapshots updated periodically by state DOTs. Timestamps shown in images indicate when each photo was captured.
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Via US-90 → US-221 → ... → Florida's Turnpike Thru Lane → US-1
Cameras shown are along this computed route
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US-1 at Mile Marker 116
FL · SB
US-1 at Mile Marker 112
FL · SB
US-1 at Mile Marker 110
FL · SB
US-1 at Mile Marker 106
FL · SB
US 1 at Jo-Jean Way
FL · SB
US-1 at Mile Marker 80
FL · SB
US-1 at Mile Marker 79
FL · SB
Rest Stops Along Your Route
45 stops available
Swipe to see moreShowing 1-2 of 45
Get Weather Alerts for This Route
We'll notify you when conditions change before your trip. Never drive into a surprise storm again.
⚡ Recent Weather Events on This Route
Premium users received alerts for these conditions:
- 🌧️Sep 27: Heavy rain expected near 27.5° - consider afternoon departure
Don't miss the next alert →
The 424-mile full-day drive from Greenville to Key West stays within FL and takes about 8h 28m without stops. We track 7 live traffic cameras, 45 rest areas and 1 active weather alert along this corridor so you can plan around them. Most drivers do this trip in one day; weather along the route matters more than the forecast at either endpoint, since you'll cross several climate zones.
7-Day Driving Outlook
Today
Sep 29
91° / 61°
3% precip
Tomorrow
Sep 30
92° / 65°
11% precip
Thu
Oct 1
91° / 70°
28% precip
Fri
Oct 2
89° / 72°
54% precip
Sat
Oct 3
91° / 72°
49% precip
Sun
Oct 4
86° / 73°
49% precip
Mon
Oct 5
79° / 73°
63% precip
🗓️ Weekend Outlook
Saturday
Use Caution⚠️ Hazardous conditions expected - Thunderstorm
Sunday
Good to Go🌧️ Moderate drizzle at origin, ☁️ Overcast at destination
Plan This Route
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Current Conditions
Greenville, FL
62°F
Wind: 4 mph
Key West, FL
78°F
Wind: 0 mph
Weather data updated in real-time
Driving from Greenville, FL to Key West, FL
The 424-mile drive from Greenville, Florida to Key West, Florida takes approximately 8h 28m under normal conditions. Weather along this route can vary significantly, especially along coastal regions where fog and marine weather can impact visibility. Route Outlook helps you find the safest time to travel by showing you weather conditions at every point along your route, timed to when you'll actually be there.
This long-distance route stays within Florida, connecting Greenville and Key West. Covering 424 miles, this is a substantial drive that will take you through diverse terrain and weather patterns. Planning ahead with real-time conditions along the entire route — not just at your destination — is essential for a safe trip.
Common Weather Hazards on This Route
- Severe thunderstorms and flash flooding (spring and summer)
- Hurricane and tropical storm impacts (June through November)
Seasonal Driving Considerations
Coastal weather on this route can shift quickly. Marine fog is common during morning hours, especially in spring and fall, reducing visibility to near zero. Hurricane season (June through November) can bring extended road closures and dangerous conditions. During fair weather, coastal routes offer scenic driving — but always verify conditions with live traffic cameras before heading out.
Best Time to Drive Greenville to Key West
For medium-distance drives like this 424-mile route, consider starting in the early morning to arrive before afternoon storms develop. Check the 7-day forecast above to find a day with favorable conditions along the entire route.
Driving Strategy
A 424-mile drive from Greenville to Key West takes a significant part of the day. Plan at least one fuel and rest stop along the way. If your route crosses elevation changes or state lines, expect weather conditions to shift mid-trip. Monitor the segment-by-segment forecast rather than just checking destination weather. Starting early in the morning typically avoids afternoon storm development and rush-hour congestion near urban areas.
Pro Tip
Use Route Outlook's departure optimizer to find the best time to leave. Our 4D trajectory engine considers weather at each point along your route at the exact time you'll be there — not just at your destination. It also integrates live data from traffic cameras, DOT 511 feeds, and road weather sensors.
Frequently Asked Questions
How long is the drive from Greenville to Key West?
The drive is approximately 424 miles and takes about 8h 28m under normal traffic and weather conditions. Severe weather can add significant time to your trip.
What's the best day to drive this route?
Based on current forecasts, Sunday, Oct 4 looks ideal. Calm winds and the best conditions this week
Is it safe to drive from Greenville to Key West today?
Current conditions show medium risk along this route. Use caution and allow extra time. Reduce speed and increase following distance as conditions warrant.
Are there rest areas on the Greenville to Key West route?
Yes, there are 45 rest areas along this route. Facilities include restrooms, parking, and in some cases picnic areas and vending machines. Rest stops are spaced throughout the drive, so you'll never be too far from a break.
Can I see live traffic cameras on this route?
Yes, Route Outlook shows 7 live traffic cameras along this route, sourced from state DOT feeds. You can check road visibility, traffic flow, and pavement conditions in real time before and during your drive.
What highways does this route use?
This route primarily uses US-1. Conditions can vary between highway segments, so check live camera feeds and road condition reports for each stretch before departing.
Are there any road closures on this route right now?
No significant incidents or road closures are currently reported along this route. Conditions can change quickly — this page updates automatically with the latest data from state DOT 511 systems.
Related Driving Guides
Finding the Safest Time to Drive: A Data-Driven Approach
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🛣️How to Check Road Conditions Before a Trip: All Your Options
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