Winona, MN → St. Louis, MO
382 mi · 7h 38m (driving)
Current Risk
Low Risk
Clear conditions along your route
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Winona
29°
Monticello
36°
McDonough County
40°
St. Louis
36°
Trip Briefing
3 segments · 382 mi · 7h 38m
Weather
🌤️ Mainly clear
36°F, wind 10 mph
Rest Stops
20
Restrooms, Truck svc
Cameras
5 live
Clear driving conditions expected
Rest stops in this segment:
- ● Nodine Truck Stop
- ● Dresbach Rest Area 🚻
- ● La Crosse Rest Area 31 🚻
Hazards Ahead
1 road closure may affect your route · 49 construction zones on route
49 Construction Zones on Route
I-90 southbound: Roadwork - Mainline Right Lane Closed from I-94 EB (Begin CC) to Off Ramp to Rest Area. Daily from 11/09/2026 to 11/13/2026, 06:00 AM - 06:00 PM, M, T, W, Th, F
I-39 southbound: Roadwork - Mainline Moving Lane Closure from Columbia - Dane CO Line to Williams Drive (Bridge Crossing). Daily from 11/05/2026 to 11/13/2026, 09:00 AM - 03:00 PM, M, T, W, Th, F (excluding Sun, Sat)
US-51 southbound: Long-term: Roadwork - Mainline Left Lane Closed on US 51 SB from Siggelkow Rd (Bridge Crossing) to Apple Blossom LA
US-51 southbound: Long-term: Roadwork - Mainline Left Lane Closed on US 51 SB from To US 51 NB to Deer Point Dr WB
US-51 southbound: Roadwork - Mainline Flagging Operation on US 51 SB from To US 51 NB to Deer Point Dr WB. Daily from 05/18/2026 to 12/15/2026, 06:00 AM - 06:00 PM, Sun, M, T, W, Th, F, Sat
US-51 southbound: Roadwork - Mainline Right Lane Closed on US 51 SB from Blackbridge Rd to Sherman St
+ 43 more zones along the route — see map for full list
Highway Message Signs
US 12/18 US 12/18 EB @ E of West Broadway (MM 264.2)
FLEX LANE | CLOSED TO TRAFFIC | SILVER ALERT | WHITE HONDA SUV | WI LIC: AZJ2923
US 12/18 US 12/18 WB @ W of Stoughton Rd (MM 265.6)
FLEX LANE | CLOSED TO TRAFFIC | SILVER ALERT | WHITE HONDA SUV | WI LIC: AZJ2923
US 12/18 US 12/18 WB @ Agriculture/Marsh Dr
FLEX LANE | CLOSED TO TRAFFIC | SILVER ALERT | WHITE HONDA SUV | WI LIC: AZJ2923
Traffic Cameras
See recent road conditions along your route
Images are snapshots updated periodically by state DOTs. Timestamps shown in images indicate when each photo was captured.
Choose your route:
Selected Route
Via US-14 East → US-61 South → ... → US-40 → I-64 West
Cameras shown are along this computed route
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U.S.61 SB @ I-90
MN · SB
I-90 at County B (French Island)
La Crosse, WI ·
I-90 at WIS 131
Monroe, WI ·
I-90/94 at County C
Juneau, WI ·
I-90/94 at WIS 23
Sauk, WI ·
I-80: I-39 at I-80 Interchange (looking south)
IL · SB
I-39/90/94 at WIS 19
Dane, WI ·
I-39/90 at Racine St/WIS 11
Rock, WI ·
I-39 SB: I-39 SB at Mile Post 68.48 (looking north)
IL · SB
I-55 SB: I-55/I-74 at Oakland
IL · SB
I-55 SB: I-55 at Grand (looking south)
IL · SB
I-55 SB: I-55/70 @ MP 19.2 (looking south)
IL · SB
Rest Stops Along Your Route
77 stops available
Swipe to see moreShowing 1-2 of 77
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⚡ Recent Weather Events on This Route
Premium users received alerts for these conditions:
- 🌧️Nov 11: Rain advisory for afternoon departures
- ❄️Nov 9: Snow expected at higher elevations - consider earlier departure
- 🌫️Nov 6: Dense fog warning for morning travel
Don't miss the next alert →
Driving from Winona, MN to St. Louis, MO covers 382 miles in roughly 7h 38m of drive time, crossing state lines. We track 12 live traffic cameras, 77 rest areas and 1 reported incident along this corridor so you can plan around them. Most drivers do this trip in one day; weather along the route matters more than the forecast at either endpoint, since you'll cross several climate zones.
7-Day Driving Outlook
Today
Nov 13
38° / 29°
No precip
Tomorrow
Nov 14
42° / 27°
No precip
Sun
Nov 15
47° / 28°
No precip
Mon
Nov 16
48° / 31°
No precip
Tue
Nov 17
51° / 36°
No precip
Wed
Nov 18
53° / 40°
No precip
Thu
Nov 19
53° / 51°
No precip
🗓️ Weekend Outlook
Saturday
Good to Go🌤️ Mainly clear at origin, ⛅ Partly cloudy at destination
Sunday
Good to Go🌫️ Fog at origin, ⛅ Partly cloudy at destination
Plan This Route
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Current Conditions
Winona, MN
29°F
Wind: 7 mph
St. Louis, MO
36°F
Wind: 8 mph
Weather data updated in real-time
Driving from Winona, MN to St. Louis, MO
The 382-mile drive from Winona, Minnesota to St. Louis, Missouri takes approximately 7h 38m under normal conditions. Weather along this route can vary significantly, especially across open plains where severe weather and high winds can develop quickly. Route Outlook helps you find the safest time to travel by showing you weather conditions at every point along your route, timed to when you'll actually be there.
This long-distance route crosses state lines from Minnesota into Missouri, connecting Winona and St. Louis. Covering 382 miles, this is a substantial drive that will take you through diverse terrain and weather patterns. Planning ahead with real-time conditions along the entire route — not just at your destination — is essential for a safe trip.
Common Weather Hazards on This Route
- Winter storms and heavy snowfall (November through April)
- Black ice on mountain passes and bridges
Seasonal Driving Considerations
The Midwest corridor of this route is susceptible to rapid weather changes. Severe thunderstorms and tornadoes are a real threat from April through June, while winter brings heavy lake-effect snow, ice storms, and dangerously low wind chill. Flat terrain means high crosswinds can affect vehicle stability year-round, especially for taller vehicles. Spring flooding can also close highway underpasses and low-lying road segments.
Best Time to Drive Winona to St. Louis
For medium-distance drives like this 382-mile route, consider starting in the early morning to arrive before afternoon storms develop. Check the 7-day forecast above to find a day with favorable conditions along the entire route.
Driving Strategy
A 382-mile drive from Winona to St. Louis takes a significant part of the day. Plan at least one fuel and rest stop along the way. If your route crosses elevation changes or state lines, expect weather conditions to shift mid-trip. Monitor the segment-by-segment forecast rather than just checking destination weather. Starting early in the morning typically avoids afternoon storm development and rush-hour congestion near urban areas.
Pro Tip
Use Route Outlook's departure optimizer to find the best time to leave. Our 4D trajectory engine considers weather at each point along your route at the exact time you'll be there — not just at your destination. It also integrates live data from traffic cameras, DOT 511 feeds, and road weather sensors.
Frequently Asked Questions
How long is the drive from Winona to St. Louis?
The drive is approximately 382 miles and takes about 7h 38m under normal traffic and weather conditions. Severe weather can add significant time to your trip.
What's the best day to drive this route?
Based on current forecasts, Tomorrow (Nov 14) looks ideal. Clear conditions expected along the entire route
Is it safe to drive from Winona to St. Louis today?
Current conditions show low risk along this route. Conditions look favorable for travel. Always stay alert and adjust speed for changing conditions.
Are there rest areas on the Winona to St. Louis route?
Yes, there are 77 rest areas along this route. Facilities include restrooms, parking, and in some cases picnic areas and vending machines. Rest stops are spaced throughout the drive, so you'll never be too far from a break.
Can I see live traffic cameras on this route?
Yes, Route Outlook shows 12 live traffic cameras along this route, sourced from state DOT feeds. You can check road visibility, traffic flow, and pavement conditions in real time before and during your drive.
What highways does this route use?
This route primarily uses US-61 South, I-90 East, I-39 South, I-55 South. Conditions can vary between highway segments, so check live camera feeds and road condition reports for each stretch before departing.
Are there any road closures on this route right now?
There is currently 1 active incident along this route that may affect your drive. Check the incident details above for specific locations and expected durations.
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🛡️Road Safety Features: Real-Time Conditions for Your Route
Real-time traffic incidents from 12 states, highway message signs, road conditions, and 25,000+ traffic cameras--integrated into your route planning.
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